Thrive – Mushroom Immune Complex

Description

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Extended Description

Details:
In recent years, there has been a significant increase in the consumption of medicinal mushroom due to an increasing number of studies identifying the therapeutic properties from various species.
Medicinal mushrooms have a notoriously high antioxidant concentration. These compounds combat oxidative stress in your body, which gives rise to inflammation and ultimately to a wide range of diseases. Specifically, medicinal mushrooms contain powerful polyphenol antioxidants. A diet high in polyphenols is associated with a lower risk of cancers and chronic conditions. Equally impressive, is their ability to promote gut and immune health.

Cordyceps Sinensis Research Summary:
-antioxidant and anti-inflammatory benefits
-help prevent or treat high blood pressure.
-compound known as cordycepin, appears able to relax blood vessels
-improves circulation and lowering blood pressure.
-relaxes airway constriction and improve quality of life measures in people with moderate to severe asthma.
-improve exercise performance.
– improve cholesterol levels and reduce weight
-able to trigger apoptosis (cell death) in breast cancer cells
– antitumor, radioprotective, antiplatelet, and antidiabetic effects.
-improved renal function and reduced nephropathy in renal transplant patients and diabetes patients with renal insufficiency undergoing coronary angiography.

Reishi Mushroom Research Summary-

-enhance immune response and decrease inflammation
-improves urinary flow in men
-reishi beta-glucans may help stop the growth and spread of cancer cells.
-reishi sterols that can act as precursors to hormones in the body
-triterpenes have blood pressure-lowering effects
-decrease high cholesterol
-stimulate cells of the immune system and immune modulation
-enhance immune response in advanced-stage cancer patients.
-antihistamine effects
-renoprotective and hepatoprotective

Shitake Mushroom Extract Research Summary-
-antiviral
-Immunostimulation
-Valued as an anticancer agent (antiproliferative, cytotoxic, antimutagenic, anticaries, and properties)
-Shitake lentinan is considered a biological response modifier
-Hepatoprotective
-Reduced High cholesterol
-enhanced gut immunity by upregulating interleukin (IL)-23 secretion
-Eritadenine from shiitake may exert antihypercholemic effects and regulate lipid metabolism
-antitumor effects by increasing serum IL-2 levels and TNF-α production, and by inducing apoptosis in tumor cells

Lion’s Mane Research Summary-
Neuroprotective
Nootropic (cognitive enhancer)
Anti-inflammatory
Increases NGF levels in the brain which enhance neuronal growth, regeneration and synaptic plasticity
Improves myelination, enhanced neuronal communication and nerve regeneratio
increases long-term synaptic potentiation thus improving memor
Decreases glutamatergic transmission resulting in decreased neuronal excitability and excitotoxicity
Protects neurons from endoplasmic reticulum stress
Anxiolytic (anti- stress)

Mitake Mushroom Research Summary-
treat diabetes and hypertension.
enhance immune function
treat HIV and cancer
Beta 1,6-glucan, a protein bound polysaccharide, has been identified as the active constituent
exhibited hypoglycemic effects in a few studies
inducing ovulation in patients with polycystic ovary syndrome
demonstrated antitumor effects
enhanced bone marrow colony formation
reduced doxorubicin toxicity
inhibited tumor metastasis
promoted maturation of hematopoietic cells to functionally active myeloid cells and enhanced peripheral blood leukocyte recovery following chemotoxic bone marrow
also enhanced interferon activity against bladder cancer cells and alleviated inflammation associated with inflammatory bowel disease
antileishmanial effects
ameliorate lipid metabolic disorders by modulating gut microbial phylotypes
regulating genes involved in hepatic lipid and cholesterol metabolism
immunomodulatory effects
enhance neutrophil and monocyte function in patients
Hypertension
• Immunostimulation by activating various effector cells, such as macrophages, natural killer cells, and T cells, as well as interleukin-1 and superoxide
• antidiabetic effect of alpha-glucan may be due to its effects on insulin receptors by increasing insulin sensitivity and ameliorating insulin resistance of peripheral target tissues
• exerted antidepressant effects in mice, involving activation of the α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors, which are important mediators for the treatment of depression

Turkey Tail Mushroom Research Summary-

Immunostimulant
anti-tumor properties
Polysaccharide-K (PSK), a proprietary product derived from Coriolus, was developed for cancer treatment in Japan. When used as an adjuvant, PSK appears to improve survival rates in patients with gastric (1) (2) and colorectal (3) (4) (5) cancers. It may also benefit patients with esophageal cancer (27).
Immunomodulatory effects
• Cancer prevention
• Cancer treatment
• Chemotherapy side effects
• Hepatitis
• Herpes
• Immunostimulation
• Infections
• Radiation therapy side effects
• Strength and stamina

Chaga Research Summary-
demonstrated antitumor, anti-mutagenic, antiviral, antiplatelet, antidiabetic, antioxidant, and analgesic effects
immunomodulating
anti-inflammatory
pain-relieving properties (3).
anti-allergic
cognition-enhancing
antioxidant activities
anti-inflammatory effects
increased exercise endurance and biological measures related to fatigue
Antidiabetic effects have also been observed
demonstrated inhibitory and proapoptotic effects against colon, lung and liver cancer cells
exerts antitumor effects against cervical cancer cells
demonstrated selective apoptosis in tumor cells with no effects on healthy Anti-inflammatory
• Cancer treatment and prevention
• Hepatoprotective
• Immunostimulation
• antidiabetic effects are attributed to terpenoids that inhibit alpha-glucosidase
• Anti-inflammatory and pain-relieving properties may occur via inhibition of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)
• Immunomodulating effects are attributed to Th1/Th2 cytokine secretion in immune cells
• regulation of antigen-specific antibody production
• Anti-quorum sensing activity in chaga conks suggests broader anti-infection attributes beyond immunomodulatory effects
• Antifatigue effects were attributed to polysaccharides from chaga, which increased endurance and glycogen content
• Anti-inflammatory effects in animal colitis models were related to suppression of tumor necrosis factor (TNF)-alpha, iNOS, and interleukin (IL)-1beta
• Water-soluble lignin derivatives have also been identified as bioactive constituents with anticancer

Royal Sun Agaricus Research Summary
anticancer
immunostimulant effects
antitumoral activity
polysaccharides and protein polysaccharide complexes displayed antiviral activity
improves liver function in patients with hepatitis B
Immunomodulating Effect by Polysaccharide is an immunologic adjuvant
Antihyperglycemic
Antihypertriglyceridemic
Antihypercholesterolemic
Antiarteriosclerotic
antidiabetic activity
antitumor
antiviral

White Button Mushroom Research Summary-
Chemopreventive
immunomodulating activities
polysaccharides and especially beta-D-glucans bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells.
this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells

Black fungus
Reliable source of prebiotics, mainly in the form of beta glucan, which enhances the immune response via gut microbiome
Hepatoprotective
anti-inflammatory
antiviral
anticoagulant
antitumor properties
multinutrient composition
Rich in Vitamin K, vital to immune health
rich in iron, as well as cellulose and a special plant collagen
Cellulose and collagen together can promote intestinal fat/food excretion, prevent constipation, and help the body to remove toxic substances (which alleviates postpartum hemorrhoids

Antioxidants

Suuggested Use

Product Information
Serving Size: 2 Capsules
Capsules Per Container: 60
Directions: Take 2 capsules daily, 20-30 minutes before a meal, with an 8 oz glass of water.

FAQ

FAQ:
Does it matter what part of the mushroom is used?
The short answer is YES! Mushroom fruiting body extracts offer a more potent and higher quality product than mycelium extracts. Concentrated fruiting body extracts contain more bioactive levels of beta-glucans and a wider array of nutritional components, compared to the mycelium.

Are there any contraindications or side effects? Even though medicinal mushrooms are generally considered completely safe to consume, we always recommend consulting your doctor before changing your supplement regiment, especially if you have any medical conditions or are currently pregnant.

Why should I consider using medicinal mushrooms? Medicinal mushrooms have many unique characteristics and uses, specific to each mushroom. Generally, medicinal mushroom have historically been used to Boost immediate and long term immune response, anti-aging constituents, enhance memory and cognitive function, improves and supports mood, elevates endurance, and disease prevention. As research and trials continue to validate clinical applications, our understanding of these powerhouse fungi also continue to grow.
How long will it take for my medicinal mushrooms to kick in? Medicinal mushrooms are classified as adaptogenic herbs which work slowly over long periods of time, so it can take up to a few weeks for their effects to make themselves known. The benefits of medicinal mushrooms are obtained through prolonged use. For best results, it’s important to take high-quality products at known effective doses.

How are mushroom extracts made?
Medicinal mushrooms are harvested, dried and ground to a fine powder and extracted using water or alcohol solvents. This process allows for the cell wall of the raw material to be broken down, leaving the beneficial compounds (beta-glucans, triterpenes, etc.) and eliminates compounds such as chitin, which our bodies do not have the proper enzymes to break down. The resulting mushroom extract is strained, concentrated and dried. These extracts are then available for formula compounding. The intricacy of this process is just one of the many reasons it’s imperative to purchase high quality products.

Research

Research:
1. Asma Ashraf Khan, Adil Gani, Firdous A.Khanday, F.A. Masoodi (2018). Biological and pharmaceutical activities of mushroom β-glucan discussed as a potential functional food ingredient. Bioactive Carbohydrates and Dietary Fibre Volume 16, October 2018, Pages 1-13 https://doi.org/10.1016/j.bcdf.2017.12.002
2. McCleary, B. V., & Draga, A. (2016). Measurement of Beta-Glucan in mushrooms and mycelial products. Journal of AOAC International, 99(2), 364–373. http://doi.org/10.5740/jaoacint.15-0289
3. Novak M, Vetvicka V (2008). Beta-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol. 2008 Jan;5(1):47-57. doi: 10.1080/15476910802019045.
4. Sari, M., Prange, A., Lelley, J. I., & Hambitzer, R. (2017). Screening of beta-glucan contents in commercially cultivated and wild growing mushrooms. Food Chemistry, 216, 45–51.
5. Chilton, J. Nammex: Redefining Medicinal Mushrooms, 2015
6. Stengler, Mark. (2005). The Health Benefits of Medicinal Mushrooms. Basic Health Publications, Inc.
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11. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regime: Cordyceps sinensis, Part II. J Altern Complement Med 1998;4:429-57.
12. Xu F, et al. Amelioration of cyclosporin nephrotoxicity by Cordyceps sinensis in kidney-transplant recipients. Nephrol Dial Transplant 1995;10:142-3.
13. Huang B, et al. Cordyceps sinensis and its fractions stimulate MA-10 mouse Leydig tumor cell steroidogenesis. J Androl 2001;22:831-7.
14. Nakamura K, et al. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. Jpn J Pharmacol1999;79:335-41.
15. Chiu JH, et al. Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens in human hepatoma cell line HA22T/VGH cells. Am J Chin Med1998;26:59-70.
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53. Chan WK, Cheung CC, Law HK, et al. Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. J Hematol Oncol. 2008;1(1):9.
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96. Isoda N, Eguchi Y, Nukaya H, et al. Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma. Hepatogastroenterology. 2009 Mar-Apr;56(90):437-41.
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https://www.ncbi.nlm.nih.gov/pubmed/11739882
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